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Hereditary Research Laboratory

Publications

• Dan Doherty Albert E. Chudley, Gail Coghlan, Gisele E. Ishak, A. Micheil Innes, Edmond . Lemire, R. Curtis Rogers,7 Aizeddin A. Mhanni,2 Ian G. Phelps,1 Steven J.M. Jones,Shing H. Zhan, Anthony P. Fejes, Hashem Shahin, Moien Kanaan, Hatice Akay,Mustafa Tekin, FORGE Canada Consortium,1Barbara Triggs-Raine, and Teresa Zelinski. 2012. GPSM2 Mutations Cause the Brain Malformations and Hearing Loss in Chudley-McCullough Syndrome. The American Journal of Human Genetics (2012),doi:10.1016/j.ajhg.2012.04.00

• Silvia Dossena, Charity Nofziger, Zippora Brownstein, Moien Kanaan, Karen B. Avraham and Markus Paulmichl. 2011;Functional characterization of Pendrin mutations found in the Israeli and Palestinian populations. Cell Phys Biochem:28(3):477-84

• XX Ovarian Dysgenesis Is Caused by a PSMC3IP/HOP2 Mutation that Abolishes Coactivation of Estrogen-Driven Transcription. David Zangen, Yotam Kaufman, Sharon Zeligson, Shira Perlberg, Hila Fri, Moein Kanaan, Maha Abdulhadi Atwan, Abdulsalam Abu Libdeh, Ayal Gussow, Liran Carmel, Paul Renbaum, and Ephrat Levy-Lahad. 2011.The Am J. of Hum Gene: 89, 572–579.

• Zippora Brownstein, Lilach M Friedman, Hashem Shahin, Varda Oron-Karni, Nitzan Kol, Amal Abu Rayyan, Thomas Parzefall, Dorit Lev, Stavit Shalev, Moshe Frydman, Bella Davidov, Mordechai Shohat, Michele Rahile, Sari Lieberman, Ephrat Levy-Lahad, Ming K Lee, Noam Shomron, Mary-Claire King, Tom Walsh, Moien Kanaan and Karen B Avraham. 2011.Targeted genomic capture and massively parallel sequencing to identify genes for hereditary hearing loss in Middle Eastern families. Genome Biology:12:9-15

• Borck G, Rainshtein L, Hellman-Aharony S, Volk AE, Friedrich K, Taub E, Magal N, Kanaan M, Kubisch C, Shohat M, Basel-Vanagaite. 2011.High frequency of autosomal-recessive DFNB59 hearing loss in an isolated Arab population in Israel, Clin Genet. Jun 23. doi: 10.1111/j.1399-0004.2011.01741.x. Epub ahead of print

• Randa Kattan, Amal Abu Rayyan, Inas Zheiman, Suzan Idkeidek, Sabri Baraghithi, Nabeel Rishmawi, Sultan Turkuman, Afaf Abu-Diab, Riyad Ghneim, Madeleine Zoughbi, Rula Dauodi, Raed Ghneim, Abed-El-Razeq Issa, Issa Siryani, Randa Al Qas, Rawan Liddawi, Hatem Khamash, Moein Kanaan, Hiyam Marzouqa, and Musa Y. Hindiyeh.2011. SerotypeDistribution and Drug Resistance in Streptococcus pneumoniae, Palestinian Territories. Emerging Infectious Diseases 17, No. 1, January

• Walsh VL, Raviv D, Dror AA, Shahin H, Walsh T, Kanaan MN, Avraham KB, King MC. A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIA.. Mammalian Genome, 22, (8) 170-178, 2011

• Tayfun Özçelik, Moien Kanaan, Karen B Avraham, Drakoulis Yannoukakos, André Mégarbané, Ghazi O Tadmouri, Lefkos Middleton, Giovanni Romeo, Mary-Claire King & Ephrat Levy-Lahad Collaborative genomics for human health and cooperation in the Mediterranean region, Nature,42 (8) 2010.

• Asli Sirmaci, Seyra Erbek, Justin Price, Mingqian Huang, Duygu Duman, F. Basak Cengiz, Guney Bademci, Suna Tokgoz-Yilmaz, Burcu Hismi, Hilal Ozdag, Banu Öztürk, Sevsen Kulaksizoglu, Erkan Yildirim, Haris Kokotas, Maria Grigoriadou, Michael B. Petersen, Hashem Shahin, Moien Kanaan, Mary-Claire King, Zheng-Yi Chen, Susan H. Blanton, Xue Z. Liu, Stephan Zuchner, Nejat Akar, and Mustafa Tekin. A Truncating Mutation in SERPINB6 Is Associated with Autosomal-Recessive Nonsyndromic Sensorineural Hearing Loss, AM J Hum Genet. 86,1-8, 2010

• Walsh T, Pierce SB, Lenz DR, Brownstein Z, Dagan-Rosenfeld O, Shahin H, Roeb W, McCarthy S, Nord AS, Gordon CR, Ben-Neriah Z, Sebat J, Kanaan M, Lee MK, Frydman M, King MC, Avraham KB: Genomic duplication and overexpression of TJP2/ZO-2 leads to altered expression of apoptosis genes in progressive nonsyndromic hearing loss DFNA51. Am J Hum Genet. 87(1):101-9, 2010. 

• Hashem Shahin, Tom Walsh, Amal Abu Rayyan, Ming K. Lee, Jake Higgins, Karen B. Avraham, Mary-Claire King, Moien Kanaan: Whole Exome Sequencing and Homozygosity Mapping Identify Mutation in the Cell Polarity Protein GPSM2as the Cause of Nonsyndromic Hearing Loss DFNB82, Am J Hum Genet: 87, 1–5, 2010.

• Hashem Shahin, Michael Rahil, Amal Abu Rayan, Karen B. Avraham, Mary-Claire King, Moien Kanaan, Tom Walsh: Truncation of PTPRQ is responsible for human hearing loss and vestibular dysfunction, J Med Genet;47:643-645,2010

• Hashem Shahin, Tom Walsh, Amal Abu Rayyan, Ming K. Lee, Jake Higgins, Karen B. Avraham, Mary-Claire King, Moien Kanaan: Five novel loci for inherited hearing loss mapped by SNP-based homozygosity profiles in Palestinian families. European Journal of Human Genetics:18, 407–4131-7, 2010

• Walsh T, Abu Rayan A, Abu Sa’ed J, Shahin H, Lee MK, Hirschberg K, Tekin M, Avraham KB, King M-C, Kanaan M: Genomic analysis of a heterogeneous Mendelian phenotype: Multiple novel alleles for inherited hearing loss in the Palestinian population. Human Genomics 2: 203-211, 2009.

• Abu Sa'd J, Indelman M, Pfendner E, Falik-Zaccai TC, Mizrachi M, Shalev S, Ben Amitai D, Raas-Rothshild A, Adir-Shani A, Borochowitz Z, Gershoni R, Abu-Libdeh BY, Khayat M, Landau D, Richard G, Bergman R, Uitto J, Kanaan M, Sprecher E (2008). Molecular epidemiology of hereditary epidermolysis bullosa in a Middle Eastern population. J Invest Dermatol, 127,777-781 

• Shahin H, Walsh T, Sobe T, Abu Sa'ed J, Abu Rayan A, Lee MK, Avraham KB, King M-C, Kanaan M (2006). Mutations in a novel isoform of TRIOBP that encodes a filamentous actin binding protein are responsible for DFNB28 recessive non-syndromic hearing loss. Amer J Human Genet 78: 144-152.

• Nasereddin A, Baneth G, Schonian G, Kanaan M, Jaffe CL. (2005) Molecular fingerprinting of Leishmania infantum strains following an outbreak of visceral leishmaniasis in central Israel. J Clin Microbiol 43: 6054-6059.

• del Castillo FJ, Rodriguez-Ballesteros M, lvarez A, Hutchin T, Leonardi E, de Oliveira CA, Azaiez H, Brownstein Z, Avenarius MR, Marlin S, Pandya A, Shahin H, Siemering KR, Weil D, Wuyts W, Aguirre LA, Martin Y, Moreno-Pelayo MA, Villamar M, Avraham KB, Dahl HHM, Kanaan M, Nance WE, Petit C, Smith RJH, Van Camp G, Sartorato EL, Murgia A, Moreno F, delCastillo I (2005). A novel deletion involving the connexin-30 gene, del (GJB6-D13S1854), found in trans with mutations in the GJB2 gene (connexin-26) in subjects with DFNB1 non-syndromic hearing impairment. J Med Genet 42: 588–594.

• Schnur LF, Nasereddin A, Eisenberger CL, Jaffe CL, El Fari M, Azmi K, Anders G, Killick-Kendrick M, Killick-Kendrick R, Dedet J-P, Pratlong F, Kanaan M, Grossman T, Jacobson RL, Schonian G, Warburg A. (2004) Multifarious characterization of Leishmania Tropica from a Judean Desert focus, exposing intraspecific diversity and incriminating Phlebotomus Sergenti as its vector. Amer J Trop Med Hyg 70: 364–372

• Ciubutaro D, Bergman R, Baty D, Indelman M, Pfender E, Petronius D, Moualem H, Kanaan M, Ben Amitai D, McLean WHI, Uitto J, Sprecher EJ. (2003) Epidermolysis bullosa simplex in Israel: Clinical and genetic features. Arch Dermatology 139: 498-505

• Kanaan M and Shahin H. (2003). Guidelines for Palestinian Families with Children with Hearing Loss, Bethlehem University Publication.

• Green GE, Mueller RF, Cohn ES, Avraham KB, Kanaan M, Smith RJH. (2003). Audiological manifestations and features of connexin 26 deafness. Audiology Med 1: 5-11.

• Cohen-Sacks H, Najajreh Y, Tchaikovski V, Gao G, Elazer V, Dahan R, Gati I, Kanaan M, Waltenberger J, Golomb G. Novel PDGFbetaR antisense encapsulated in polymeric nanospheres for the treatment of restenosis. (2003) Gene Therapy 9: 1607-1616.

• Novel PDGF_R antisense encapsulated in polymeric nanospheres for the treatment of restenosis.(2002) H Cohen-Sacks, Y Najajreh,, V Tchaikovski, G Gao, V Elazer, R Dahan, I Gati, M Kanaan, J Waltenberger3 and G Golomb. Gene Therapy :9, 30-39

• Walsh T, Walsh V, Vreugde S, Hertzano R, Shahin H, Haika S, Lee MK, Kanaan M, King M-C, Avraham KB. (2002). From flies to our ears: Mutations in a human class III myosin cause progressive nonsyndromic hearing loss DFNB30. Proc Nat Acad Sci USA 99: 7518-7523.

• Zwaenepoel I, Mustapha M, Leibovici M, Verpy E, Goodyear R, Liu XZ, Nouaille S, Nance WE, Kanaan M, Tekaia F, Loiselet J, Weissenbach J, Lathrop M, Richardson G, Petit C (2002) Otoancorin, an inner ear protein restricted to the interface between the apical surface of sensory epithelia and their overlying acellular gels, is defective in autosomal recessive deafness DFNB22. Proc Nat Acad Sci USA 99: 6240-6245.

• Nakano A, Gilles G, Lestringant G, Paperna T, Bergman R, Gershoni R, Frossard P, Kanaan M, Meneguzzi G, Richard G, Pfendner E, Uitto J, Pulkkinen L, Sprecher E (2002) Junctional Epidermolysis bullosa in the Middle East: Clinical and genetic studies in a series of consanguinous families. J Am Acad Dermatol 46: 510-515.

• El-Latif MA, Filon D, Rund D, Oppenheim A, Kanaan M (2002). The beta+IVS-1-6 (T>C) accounts for half of the thalassemia chromosomes in the Palestinian population of the mountain regions. Hemoglobin 26: 33-40.

• Shahin H, Walsh T, Sobe T, Lynch E, King M-C, Avraham KB, Kanaan M (2002) Genetics of congenital deafness in the Palestinian population: Multiple connexin 26 alleles with shared origins in the Middle East. Hum Genet 110: 284-289. 

• Sobe T, Vreugde S, Shahin H, Berlin M, Kanaan M, Yaron Y, Orr-Urtreger A, Frydman M, Shohat M, Avraham KB (2000). Prevalence and expression of inherited connexin 26 mutations associated with nonsyndromic hearing loss in the Israeli population. Hum Genet 106: 50-57.

• Kanaan MN. (1999) High concordance between quantitative antibiogram and pulse field macrorestriction analysis in typing methicillin-resistant Staphylococcus aureus. Epidemiology 23: 145-148.

• Kanaan MN. (1997) Molecular strategies for typing and properties of epidemic methicillin-resistant Staphylococcus aureus. J Hos Infec 15: 12-17.

• Kanaan MN (1996) Can we control MRSA-strains in hospitals in Palestine? Bethlehem J 15: 106-113.

• Marzluf GA, Kanaan MN. (1995) Molecular analysis of DNA-binding, trans-acting regulatory proteins. Bethlehem J 14: 21-33.

• Muller F, Kruger D, Sattelgger E, Hoffmann B, Wende A, Ballario P, Kanaan M, Barthelmess IB (1995). Cpc-2, a gene encoding a highly conserved protein with a repetitive segmental structure involved in general amino acid control and female fertility. Mol Gen Genet 248: 162-173.

• Kanaan MN, Marzulf GA (1993) The positive acting regulatory protein CYC3: Nuclear localization, autogenous control and regions required for transcriptional activation. Mol Gen Genet 239: 334-344.

• Kanaan MN, Marzuluf GA (1992) The DNA binding domain of the CYS3 regulatory gene is bipartite. J Biochem 31: 3197-3203.

• Kanaan MN, Marzluf GA. (1991) Mutational analysis of the DNA binding domain of the CYS-3 regulatory gene. Mol Cell Biol 11: 4356-4359.

• Olson GB, Kanaan MN, Kelly LM, Jones JF. (1988) Specific allergen-induced Epstein-Barr nuclear antigen-positive B-cells from patients with chronic-active Epstein-Barr virus nuclear antigen-positive B-cells from patients with chronic-active Epstein-Barr virus infections. Allergy Clin Immunol 78: 315-320. 

• Olson GB. Kanaan MN. Kelly LM, Jones JF. (1987). Correlation between allergy and persistent Epstein-Barr virus infection in chronic-active Epstein-Barr virus-infected patients. J Allergy Clin Immunol 78: 308-314.
 
 

 
 
 

 
 

 

 

 

 


 

 
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Hereditary Research Laboratory

Moien Kanaan, Ph.D.
Associate Professor - Molecular Genetics Life Science Department
Principle Investigator
Tel:9722-274-1241(2-5)
Office,or Direct line at 9722-274-4233
Fax:9722-274-4440
mkanaan@bethlehem.edu

Bethlehem University Foundation
Email: brds@bufusa.org
Phone: +1-240-241-4381
Fax: +1-240-553-7691
Beltsville, MD USA
Bethlehem University in the Holy Land
E-mail: info@bethlehem.edu
Phone: +972-2-274-1241
Fax: +972-2-274-4440
Bethlehem, Palestine